Fig. 7.

A, The modeled depolarizations mediated by synapses with only AMPARs (left), only KARs (center), or both AMPARs and KARs (right) are shown. The synapses with both AMPARs and KARs led to a large tonic depolarization, similar to the response mediated by synapses with only KARs, but with a larger variability, similar to the response mediated by synapses with only AMPARs. B, The characteristics of depolarization mediated by synapses with AMPARs, KARs, or both are shown for 1 sec blocks of the model (n = 19).B₁, The tonic (filled bars), mean (light gray bars), and peak (dark gray bars) depolarizations are shown for each population of modeled synapses. B₂, The CV of the membrane depolarization is shown for synapses with AMPARs, KARs, or both. C, The modeled depolarizations are shown for 50 fibers synapsing onto AMPARs added to 50 independent fibers synapsing onto KARs (top) and 50 fibers synapsing onto colocalized AMPARs and KARs (bottom). There was little difference between the two conditions. D, The tonic, mean, and peak depolarizations are shown, as is the CV of the depolarization, for synapses in which AMPARs and KARs were colocalized (filled bars) or segregated to different synapses (open bars).