Table 1.

Influences of Various Clinical and Pathologic Risk Factors on Overall Patient and Tumor-Free Survival

Characteristic	n	Overall patient survival				Tumor-free survival
		3 y (%)	5 y (%)	10 y (%)	P Value	3 y (%)	5 y (%)	10 y (%)	P Value
Patient
Gender
Male	178	49.3	33.5	24.7	NS	34.9	28.2	24.7	<0.03
Female	127	47.1	30.5	23.3		26.4	15.7	13.5
Age (y)
≤60	143	51.5	36.5	28.6	NS	32.1	23.8	21.0	NS
> 60	162	46.6	28.2	19.0		30.5	22.3	18.8
Primary tumor
Site
Rectum	78	50.1	40.5	31.1	NS	37.6	26.0	21.4	NS
Left colon	156	50.8	30.9	20.0		31.5	22.0	18.6
Right colon	71	41.2	26.4	24.2		23.6	21.6	21.6
Dukes classification
A + B	75	60.3	44.9	31.5	NS	39.9	28.8	28.8	< 0.06
C	141	42.8	27.4	21.5		27.4	19.9	18.8
D (synchronous)	89	47.1	28.6	20.9		30.4	22.8	14.7
Dukes classification
A + B	75	60.3	44.9	31.5	< 0.053	39.9	28.8	28.8	< 0.002
C + D	230	44.6	28.1	21.8		28.4	20.9	16.8
Lymph node
Negative	148	56.9	36.8	27.3	< 0.03	35.9	25.9	24.7	< 0.02
Positive	154	39.9	27.7	21.3		26.7	20.5	16.6
Hepatic metastases
Interval (mo)
≤ 12	132	48.8	28.7	25.1	NS	28.8	24.0	21.9	NS
12–24	77	38.8	30.9	20.7		25.1	19.7	17.5
25–36	42	48.1	40.5	21.6		34.2	15.4	7.7
36–48	22	65.7	23.6	23.6		40.0	21.0	21.0
> 48	32	58.2	45.8	32.8		47.0	37.6	32.3
Interval (mo)
≤ 30	235	44.6	29.9	22.5	< 0.04	27.6	20.9	18.2	< 0.01
> 30	70	61.4	40.1	29.6		43.3	29.3	26.4
No. of tumors
1	137	57.3	41.4	32.3	< 0.001	40.9	33.1	31.0	< 0.0001
2	75	50.6	37.6	24.9		35.0	22.8	17.8
3	31	38.4	11.7	–		19.4	14.5	–
≥ 4	62	31.4	16.1	10.7		11.9	5.0	–
No. of tumors
1–2	212	55.0	40.2	29.8	< 0.0001	38.8	29.4	26.3	< 0.0001
≥ 3	93	33.8	14.6	11.2		14.4	8.1	–
Size (cm)
≤ 2	15	58.2	43.6	29.1	NS	46.7	46.7	46.7	NS
2–5	152	51.0	32.0	23.4		31.8	25.1	21.7
5–10	102	45.8	34.4	26.3		29.6	17.7	15.8
> 10	31	39.9	20.7	15.4		27.8	17.4	11.6
Size (cm)
≤ 8	257	50.9	34.6	25.5	< 0.03	33.5	24.9	22.0	< 0.02
> 8	48	34.7	19.3	16.1		18.8	11.7	7.8
Distribution
Unilobar	200	56.0	39.2	29.2	< 0.0001	38.0	28.7	26.0	<0.0001
Bilobar	105	33.8	18.9	13.9		18.2	11.7	8.9
Node metastasis
No	296	49.5	32.9	24.5	< 0.007	31.9	23.4	20.4	< 0.05
Yes	9	11.1	–	–		11.1	–	–
Metastasis
No	273	51.1	34.6	26.2	< 0.0001	34.5	25.3	22.9	< 0.0001
Yes	32	20.8	5.5	0		0	0	0
Differentiation
Grade 1	59	50.4	39.6	32.1	NS	39.4	28.1	28.1	NS
Grade 2	239	48.1	30.2	21.8		29.2	22.0	17.4
Grade 3	7	42.9	28.6	–		28.6	14.3	0
Surgery
Margin
> 1 cm	130	54.2	38.4	26.7	< 0.003	38.5	28.9	27.0	< 0.0008
≤ 1 cm	147	48.4	31.4	25.8		30.2	22.2	18.1
Involved	28	20.9	8.4	0		4.8	0	0
Resection
Multiple wedges	20	38.9	13.0	0	< 0.03	16.0	0	0	< 0.006
More than lobe	85	33.3	21.1	19.3		17.1	15.4	13.7
Lobectomy	158	54.7	37.2	25.3		36.6	24.8	22.9
Less than lobe	42	57.5	40.6	34.8		41.1	37.6	26.9
Adjuvant therapy
No	103	44.4	33.6	23.0	NS	33.4	24.2	24.2	NS
Yes	202	50.4	31.3	24.5		30.3	22.4	18.2
Surgery for recurrence
No	197	27.0	7.7	0.9	< 0.0001	8.6	2.5	0	< 0.002
Yes	32	87.5	77.2	52.2		30.2	6.7	3.4