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. Author manuscript; available in PMC: 2010 Nov 2.
Published in final edited form as: Cell Mol Bioeng. 2008 Dec 1;1(4):229–239. doi: 10.1007/s12195-008-0028-4

FIGURE 5.

FIGURE 5

Implication of signaling pathways influencing the actin cytoskeleton in the SPR signal variation. In (a), (b) and (c) are presented phase-contrast micrographs recorded before (−2 min) and after AngII stimulation (2 and 40 min) for cell treatment with inhibitors targeting respectively the MLCK (20 μM, ML-9), RhoK (10 μM, Y-27632) or directly the actomyosin contraction (100 μM, blebbistatin). (d) Summary of the amplitudes in the initial decrease of the SPR signal (n = 5). ††p<0.01 versus HBSS stimulation, **p<0.01 versus AngII stimulated cells. The scale bars correspond to 10 μm.