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. Author manuscript; available in PMC: 2010 Nov 2.
Published in final edited form as: Methods Enzymol. 2009;455:95–125. doi: 10.1016/S0076-6879(08)04204-3

Figure 5. Unfolding and 1D-Ising analysis of consensus ankyrin repeat proteins with and without terminal caps.

Figure 5

Constructs are described in the text (TA and DB, in preparation). Lines result from fitting a heteropolymer partition function, assuming N- and C-caps and the internal consensus repeats (R) all have different intrinsic folding energies. The effect of guanidine is partitioned into intrinsic folding energies and is assumed to be the same for all types of repeats. Different contributions of the N-, C- and R repeats can be seen by noting the shifts between constructs containing the same number of repeats, but different identities.