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. 2010 Oct;23(5):457–466. doi: 10.1089/vim.2010.0051

FIG. 4.

FIG. 4.

Serum cytokine levels in PRRSV- and PRCV-infected pigs. Pigs were mock-infected (n = 43), or infected with PRRSV (n = 39), PRCV (n = 48), or PRCV/PRRSV (n = 48), and serum was collected on the indicated post-inoculation days and assayed for different cytokines by ELISA. (A) IL-12, (B) IL-6, (C) IL-10, and (D) TGF-β. Each data point represents the average cytokine levels of 5–48 pig serum samples collected on the indicated post-inoculation days ± SEM. “a” denotes a statistically significant difference (p < 0.05) between the mock- and dual-infected groups; “b” denotes a statistically significant difference (p < 0.05) between the PRCV- and dual-infected groups; “c” denotes a statistically significant difference (p < 0.05) between the PRCV- and PRRSV-infected groups; and “d” denotes a statistically significant difference (p < 0.05) between the mock- and PRRSV-infected groups, as analyzed by the nonparametric Kruskal-Wallis test. Asterisks indicate a statistically significant difference for repeated sera collected from the respective pig groups (those infected with PRRSV alone and those infected with both viruses), as analyzed by repeated-measures ANOVA.