Table 5.
Primary Mixed Effects Regression Modeling Analyses of Neurobehavioral Outcomes: NRS-R and BCL2 tSNPs
| |
|
Genotypes |
Dichotomized genotypes |
||||
|---|---|---|---|---|---|---|---|
| tSNP | Variables | coefff | p | coefff | p | ||
| rs1026825 | Genotype | AA | −2.68 | 0.23 | GG & AG | 2.63 | 0.20 |
| (n = 99) | GG | −0.11 | 0.96 | AA | reference | ||
| AG | reference | ||||||
| overall | 0.45 | ||||||
| Months | 3 | 0.07 | 0.96 | 3 | 0.05 | 0.97 | |
| 6 | −0.54 | 0.69 | 6 | −0.55 | 0.69 | ||
| 12 | reference | 12 | reference | ||||
| overall | 0.88 | overall | 0.88 | ||||
| Age | 0.24 | 0.002* | 0.24 | 0.002* | |||
| GCS | 2.67 | 0.23 | 2.68 | 0.23 | |||
| Gender | −0.55 | 0.82 | −0.56 | 0.81 | |||
| rs12454712 | Genotype | CC | 0.99 | 0.77 | CC & CT | 4.44 | 0.01* |
| (n = 99) | TT | −4.28 | 0.02* | TT | reference | ||
| CT | reference | ||||||
| overall | 0.05* | ||||||
| Months | 3 | −0.16 | 0.91 | 3 | −0.19 | 0.90 | |
| 6 | −0.68 | 0.62 | 6 | −0.68 | 0.62 | ||
| 12 | reference | 12 | reference | ||||
| overall | 0.87 | overall | 0.87 | ||||
| Age | 0.25 | 0.001*** | 0.25 | 0.001*** | |||
| GCS | 2.05 | 0.34 | 2.04 | 0.34 | |||
| Gender | −2.08 | 0.36 | −2.00 | 0.37 | |||
| rs1481031 | Genotype | AA | −0.60 | 0.77 | GG & AG | 1.42 | 0.47 |
| (n = 97) | GG | 4.57 | 0.14 | AA | reference | ||
| AG | reference | ||||||
| overall | 0.26 | ||||||
| Months | 3 | 0.87 | 0.54 | 3 | 0.81 | 0.57 | |
| 6 | 0.04 | 0.97 | 6 | −0.03 | 0.98 | ||
| 12 | reference | 12 | reference | ||||
| overall | 0.78 | overall | 0.80 | ||||
| Age | 0.23 | 0.004* | 0.25 | 0.002* | |||
| GCS | 1.71 | 0.46 | 2.02 | 0.38 | |||
| Gender | −0.77 | 0.74 | −1.05 | 0.66 | |||
| rs17756073 | Genotype | AA | −3.26 | 0.10 | GG & AG | 3.07 | 0.10 |
| (n = 96) | GG | −0.75 | 0.80 | AA | reference | ||
| AG | reference | ||||||
| overall | 0.25 | ||||||
| Months | 3 | 0.09 | 0.95 | 3 | 0.08 | 0.95 | |
| 6 | −0.49 | 0.73 | 6 | −0.50 | 0.72 | ||
| 12 | reference | 12 | reference | ||||
| overall | 0.90 | overall | 0.90 | ||||
| Age | 0.24 | 0.002* | 0.24 | 0.002* | |||
| GCS | 2.47 | 0.27 | 2.49 | 0.26 | |||
| Gender | −0.71 | 0.76 | −0.72 | 0.76 | |||
| rs17759659 | Genotype | AA | −2.13 | 0.28 | GG & AG | 3.59 | 0.05* |
| (n = 98) | GG | 5.51 | 0.03* | AA | reference | ||
| AG | reference | ||||||
| overall | 0.02* | ||||||
| Months | 3 | −0.01 | 1.00 | 3 | −0.09 | 0.95 | |
| 6 | −0.63 | 0.65 | 6 | −0.71 | 0.60 | ||
| 12 | reference | 12 | reference | ||||
| overall | 0.87 | overall | 0.85 | ||||
| Age | 0.28 | 0.0002*** | 0.28 | 0.0002*** | |||
| GCS | 2.62 | 0.22 | 2.79 | 0.20 | |||
| Gender | −1.30 | 0.55 | −1.21 | 0.59 | |||
| rs1944419 | Genotype | AA | 3.88 | 0.10 | TT & AT | −4.46 | 0.05* |
| (n = 96) | TT | −2.03 | 0.38 | AA | reference | ||
| AT | reference | ||||||
| overall | 0.10 | ||||||
| Months | 3 | 0.07 | 0.96 | 3 | 0.03 | 0.98 | |
| 6 | −0.88 | 0.54 | 6 | −0.93 | 0.52 | ||
| 12 | reference | 12 | reference | ||||
| overall | 0.75 | overall | 0.74 | ||||
| Age | 0.24 | 0.002* | 0.25 | 0.001*** | |||
| GCS | 3.56 | 0.12 | 3.41 | 0.13 | |||
| Gender | −1.50 | 0.52 | −1.38 | 0.55 | |||
| Genotype | AA & AT | 3.13 | 0.16 | ||||
| TT | reference | ||||||
| Months | 3 | 0.01 | 0.99 | ||||
| 6 | −0.87 | 0.54 | |||||
| 12 | reference | ||||||
| overall | 0.77 | ||||||
| Age | 0.24 | 0.003* | |||||
| GCS | 2.84 | 0.21 | |||||
| Gender | −1.34 | 0.56 | |||||
| rs4456611 | Genotype | CC | −2.31 | 0.36 | CC & CT | −4.14 | 0.06† |
| (n = 94) | TT | 3.48 | 0.14 | TT | reference | ||
| CT | reference | ||||||
| overall | 0.12 | ||||||
| Months | 3 | 0.98 | 0.50 | 3 | 0.98 | 0.50 | |
| 6 | 0.09 | 0.95 | 6 | 0.08 | 0.95 | ||
| 12 | reference | 12 | reference | ||||
| overall | 0.75 | overall | 0.75 | ||||
| Age | 0.26 | 0.001*** | 0.26 | 0.001*** | |||
| GCS | 1.70 | 0.47 | 1.06 | 0.64 | |||
| Gender | −2.71 | 0.25 | −2.51 | 0.28 | |||
| rs7236090 | Genotype | CC | −6.02 | 0.007* | CC & CT | 5.69 | 0.005* |
| (n = 95) | TT | −0.93 | 0.68 | TT | reference | ||
| CT | reference | ||||||
| overall | 0.02* | ||||||
| Months | 3 | 1.05 | 0.47 | 3 | 0.97 | 0.50 | |
| 6 | 0.25 | 0.85 | 6 | 0.19 | 0.89 | ||
| 12 | reference | 12 | reference | ||||
| overall | 0.75 | overall | 0.77 | ||||
| Age | 0.20 | 0.01* | 0.20 | 0.01* | |||
| GCS | 1.53 | 0.48 | 1.53 | 0.48 | |||
| Gender | −0.73 | 0.76 | −0.76 | 0.74 | |||
*
p ≤ 0.05; ***p ≤ 0.001; †trend; ***p ≤ 0.001 meets Bonferroni correction.
Overall = p for type 3 test.
tSNP, tagging single nucleotide polymorphism; NRS-R, Neurobehavioral Rating Scale–Revised.
Month = time point of the outcome assessment post-injury (3, 6, and 12 months).