Effect of ratio of Eufectin
to HYB0432 on TS expression. RKO cells were incubated with different
Eufectin:HYB0432 combinations. After 6 h, complexes were removed
and fresh RPMI medium was added. After an additional 24 h, cells
were harvested and processed for western blot analysis as described
in Materials and Methods. Lane 1 contains cell extracts from untreated
RKO cells. Lanes 2–6 contain 190 nM HYB0432 complexed with
Eufectin in weight ratios of 1:1 (lane 2), 1:3 (lane 3), 1:5 (lane
4), 1:7 (lane 5) and 1:9 (lane 6). Lane 7 contains cell extracts
treated with Eufectin alone (10 µg/ml).