Western blot analysis of
RKO cells after treatment with HYB0432. Cells were incubated in
the absence (lane 1) or presence (lanes 2–8) of Eufectin–ORN
complexes (5:1 ratio; µg:µg)
for 6 h, grown for an additional 24 h and then harvested and processed
for western blot analysis as described in Materials and Methods.
Extracts in lanes 2–5 were treated with complexes containing
63, 126, 190 and 250 nM HYB0432, respectively. Cells were treated
with various control ORNs: lane 6, sense ORN HYB0848 (250 nM); lane
7, mismatch ORN HYB0503 (250 nM). Lane 8 contains cell extracts
treated with Eufectin alone (13 µg/ml).