Table 3.

Serum profiles from PCK female mice—20 mg/kg BW Pioglitazone weeks 4–18.

	Normal range	Control diet n = 12	Pio diet n = 10	P-value and significance
Na+ mM	141–148	140 ± 0.66	139 ± 0.76	.442	NS
K+ mM	4.3–5.9	4.92 ± 1.82	4.6 ± 0.53	.687	NS
Cl− mM	101–108	99.7 ± 0.54	100.5 ± 0.72	.357	NS
Calcium mg/dl	9.6–11.2	10.3 ± 0.14	9.6 ± 0.36	.060	NS
BUN mg/dL	11–17	13.6 ± 0.53	12.4 ± 0.48	.118	NS
Creatinine mg/dL	0.4–0.7	0.33 ± 0.01	0.34 ± 0.03	.754	NS
Glucose mg/dL	120–186	162 ± 6.00	146.5 ± 4.59	.055	NS
Alkaline phos. U/L	65–117	315 ± 11.18	355 ± 26.67	.060	NS
Alanine aminotransferase U/L	25–45	62 ± 3.55	70.0 ± 6.71	.171	NS
Asparagine aminotransferase U/L	72–116	136 ± 12.98	139.5 ± 20.5	.302	NS
Bilirubin mg/dL	0.2–2	0.41 ± 0.06	0.32 ± 0.04	.281	NS
Total protein gr/dL	6.4–7.5	5.5 ± 0.11	5.6 ± 0.11	.486	NS
Albumin gr/dL	3.5–5.3	1.13 ± 0.04	1.39 ± 0.03	.0001	S

Values are given as means ± SEM. Control: PCK rats on the control diet; PIO: PCK rats on a diet containing 20 mg/kg body weight pioglitazone.

n: number of animals P-values greater than  .05 were considered nonsignificant (NS).