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The schematic diagram of ING proteins expression in the malignant development of HNSCC. Nuclear expression of ING proteins is downregulated from normal squamous epithelium to dysplastic epithelium and invasive HNSCC. In contrast, the cytoplasmic expression of ING proteins in dysplastic epithelium and invasive HNSCC is gradually increased compared with normal squamous epithelium. The positive expression of ING proteins is shown with brown color.
