Table 2.

Urinary cortisol and 6-yr all-cause and cardiovascular mortality (n = 861)

	Sex- and age-adjusteda			Fully adjustedb
	HR	95% CI	P	HR	95% CI	P
All-cause mortality (no. of deaths = 183)
24-h urinary cortisolc	1.07	0.92–1.24	0.37	1.17	1.01–1.36	0.03
Tertiles of 24-h urinary cortisol
First tertile (<78 μg)		REF			REF
Second tertile (78–111 μg)	1.02	0.70–1.48	0.91	1.52	1.02–2.27	0.04
Third tertile (>111 μg)	1.12	0.78–1.61	0.54	1.74	1.15–2.62	0.009
Noncardiovascular mortality (no. of deaths = 142)
24-h urinary cortisolc	0.99	0.84–1.19	0.95	1.10	0.93–1.31	0.27
Tertiles of 24-h urinary cortisol
First tertile (<78 μg)		REF			REF
Second tertile (78–111 μg)	0.87	0.57–1.31	0.50	1.29	0.83–2.02	0.26
Third tertile (>111 μg)	0.84	0.55–1.27	0.41	1.28	0.80–2.05	0.30
Cardiovascular mortality (no. of deaths = 41)
24-h urinary cortisolc	1.31	1.01–1.72	0.05	1.42	1.06–1.90	0.02
Tertiles of 24-h urinary cortisol
First tertile (<78 μg)		REF			REF
Second tertile (78–111 μg)	1.93	0.81–4.57	0.14	2.91	1.18–7.19	0.02
Third tertile (>111 μg)	2.93	1.34–6.44	0.007	5.00	2.02–12.37	0.001

^aBased on Cox regression analyses adjusted for sex and age. 

^bAdditionally adjusted for education, smoking, alcohol intake, body mass index, waist circumference, systolic blood pressure, diastolic blood pressure, depressive symptoms, cognitive functioning, baseline cardiovascular disease, diabetes, number of other chronic diseases, 24-h urine creatinine, and urine volume. 

^cHR per sd (=48 μg) increase.