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. Author manuscript; available in PMC: 2011 Jan 15.
Published in final edited form as: J Immunol. 2009 Dec 7;184(2):725–735. doi: 10.4049/jimmunol.0902080

FIGURE 10.

FIGURE 10

Illustration of the Ab response toward Bet v 1a (A) and Bet v1d (B). A, Monomeric Bet v 1a provides only low stimulus to APCs, leading to incomplete APC activation and therefore to a higher induction of Tregs with only moderate Ab levels. Because of the absence of a protective IgG/IgA Ab response, serum IgE levels are sufficient to trigger allergic symptoms. B, As a result of self-aggregation, Bet v 1d is more immunogenic reflected by the induction of higher costimulatory molecules, thereby inducing a strong Th1/Th2-dependent Ab response with high levels of protective IgG/IgA Abs for Ag clearance.