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. 2010 Jun 26;2(5):439–445. doi: 10.1159/000317194

Table 1.

Evidence for harmful effects of C5a in sepsis

  • 1
    Protective effects of neutralizing polyclonal antibodies to C5a in CLP rats:
    • a
      Enhanced survival
    • b
      Reduced defects in innate immune system
    • c
      Reduced multiorgan failure
    • d
      Reduced intensity of coagulopathy
  • 2
    Protective effects of absence or blockade of C5a receptors in CLP mice:
    • a
      Requirement for blockade or absence of both C5aR and C5L2
    • b
      Improved survival
    • c
      Reduced cytokine storm
    • d
      Role of C5L2 in production of HMGB1
  • 3

    Unexpected effects of CLP in C5−/− mice