Table 1.
Baseline |
Hydroxy-urea |
Hydroxyurea/interferon |
On copy drug (imatinib-COPER) |
At discontinuation of copy drug |
After starting imatinib (Glivec) |
||||
---|---|---|---|---|---|---|---|---|---|
May 2002 | July 2002 (2 months on hydrox urea) | Nov2002 (4 months on f- hydroxyurea/IFN) | Sept 13, 2006 (day before starting treatment) | Nov 21,2006 (2 months after treatment) | Dec 2008 | Dec 20, 2008 | Mar 23, 2009 | May 6, 2009 | |
Red blood cell count, ×106n/mm3 | 3.51 | 3.90 | 3.91 | 2.95 | 4.01 | 3.25 | 3.42 | 3.41 | 3.61 |
Monocytes, % | 10.7 | 12.4 | 12.4 | 12.4 | 13.8 | 11.1 | 11.7 | 11.9 | 13.2 |
Total leukocyte count, n/mm3 | 207,000 | 3,000 | 11,000 | 13,500 | 8,000 | 90,690 | 54,000 | 6,980 | 7,530 |
Neutrophils, % | 56 | 52 | 70 | 62 | 69 | 45 | 58 | 64 | 54 |
Eosinophils, % | 1 | 2 | 2 | 2 | 4 | 1 | 1 | 7 | 1 |
Basophils, % | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 4 | 0 |
Lymphocytes, % | 8 | 45 | 23 | 15 | 26 | 4 | 7 | 1.6 | 41 |
Monocytes, % | 2 | 1 | 5 | 2 | 1 | 3 | 0 | 8 | 4 |
Platelet count, n/mm3 | unknown | 87,000 | 53,000 | 239,000 | 172,000 | 175,000 | 162,000 | 85,000 | 85,000 |
Myelemy | 42% | 4% | |||||||
Myeloblasts | 18% | 100% − | 100% − | 47% | 100% − | ||||
Myelocytes | 17% | no more myelemy | no more myelemy | 8% | no more myelemy | ||||
Metamyelocytes | 7% | 11% |