Fig. 1.

Caloric intake after i.p. leptin. Rats maintained on CH (a) or KD (b) were injected i.p. with saline or leptin and caloric intake was measured 24 h later. For CH rats, a dose of 2 mg/kg was required to significantly reduce caloric intake at 24 h. In contrast, KD rats reduced caloric intake in response to both 100 and 200 μg leptin. * p < 0.05 when intake was compared to intake following saline administration.