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Haptotaxis of Nf1+/– mast cells expressing NF1 GRD or R1276P mutant NF1 GRD. Nf1+/– mast cells were transduced with the control retrovirus (pac), NF1 GRD virus, or R1276P NF1 GRD virus, and haptotaxis assays were performed in response to rmKitL. Results represent the mean ± SEM of three independent experiments. *P < 0.05 for comparison of Nf1+/– pac and Nf1+/– R1276P NF1 GRD to WT pac using a Student’s paired t test.
