Figure 3.

The relationship between adipocyte size and the percentage of macrophages in adipose tissue. Average adipocyte cross-sectional area and the percentage of F4/80⁺ cells (macrophages) in adipose tissue depots were determined for each mouse in this study. Average adipocyte cross-sectional area was a strong predictor of the percentage of F4/80⁺ cells in (a) perigonadal (r² = 0.76, P < 10^–4), (b) perirenal (r² = 0.73, P < 10^–4), (c) mesenteric (r² = 0.9, P < 10^–4), and (d) subcutaneous (r² = 0.39, P < 0.01) adipose tissue depots. (e) Data collected from all mice and all depots were plotted together. Light gray and dark gray symbols denote female and male mice, respectively. ⁺, lean; triangles, Ay/⁺; squares, DIO; circles, Lepob/ob mice.