Figure 2.

Paw-withdrawal threshold in pain models. Pain models were induced as follows: intradermal carrageenan injection (1% in a volume of 5 μl), intravenous oxaliplatin administration (2 mg/kg, early-phase and late-phase groups), and alcoholic diet; controls received no prior treatment. Responses were not significantly different among the pain models, but all models demonstrated significant mechanical hyperalgesia compared to control animals; n = 4 for all groups.