TABLE III.
PEMT Met212Val and Val95Ile Compound Genotype, Maternal Ethnicity, and Risk of Spina Bifida
| Combined genotype | Cases (%) | Control (%) | OR (95% CI) |
|---|---|---|---|
| Overall | |||
| Met212/Met212 + Val95/Val 95 | 48 (14.5) | 48 (8.9) | Referent |
| Met212/Met212 + Val95/Ile95 | 66 (20.0) | 120 (22.2) | 0.55 (0.33–0.91)a |
| Met212/Met212 + Ile95/Ile95 | 34 (10.3) | 66 (12.2) | 0.52 (0.29–0.92)a |
| Met212/Val212 + Val95/Val95 | 54 (16.4) | 98 (18.1) | 0.55 (0.33–0.93)a |
| Met212/Val212 + Val95/Ile 95 | 75 (22.7) | 108 (20.0) | 0.69 (0.42–1.14) |
| Met212/Val212 + Ile95/Ile95 | 10 (3.0) | 11 (2.0) | 0.91 (0.35–2.34) |
| Val212/Val212 + Val95/Val95 | 35 (10.6) | 76 (14.0) | 0.46 (0.26–0.81)a |
| Val212/Val212 + Val95/Ile95 | 8 (2.4) | 14 (2.6) | 0.57 (0.22–1.49) |
| Val212/Val212 + Ile/95/Ile95 | 0 | 0 | — |
| Non-Hispanic white | |||
| Met212/Met212 + Val95/Val95 | 14 (11.3) | 23 (8.5) | Referent |
| Met212/Met212 + Val95/Ile95 | 31 (25.0) | 76 (28.1) | 0.67 (0.31–1.47) |
| Met212/Met212 + Ile95/Ile95 | 18 (14.5) | 45 (16.7) | 0.66 (0.28–1.55) |
| Met212/Val212 + Val95/Val95 | 17 (13.7) | 39 (14.4) | 0.72 (0.30–1.72) |
| Met212/Val212 + Val95/Ile95 | 29 (23.4) | 61 (22.6) | 0.78 (0.35–1.74) |
| Met212/Val212 + Ile95/Ile95 | 8 (6.5) | 7 (2.6) | 1.88 (0.56–6.31) |
| Val212/Val212 + Val95/Val95 | 5 (4.0) | 13 (4.8) | 0.63 (0.19–2.16) |
| Val212/Val212 + Val95/Ile95 | 2 (1.6) | 6 (2.2) | — |
| Val212/Val212 + Ile/95/Ile95 | 0 | 0 | — |
| Hispanic white | |||
| Met212/Met212 + Val95/Val95 | 29 (17.3) | 21 (10.7) | Referent |
| Met212/Met212 + Val95/Ile95 | 28 (16.7) | 37 (18.9) | 0.55 (0.26–1.16) |
| Met212/Met212 + Ile95/Ile95 | 10 (6.0) | 19 (9.7) | 0.38 (0.15–0.99)a |
| Met212/Val212 + Val95/Val95 | 34 (20.2) | 43 (21.9) | 0.57 (0.28–1.18) |
| Met212/Val212 + Val95/Ile95 | 37 (22.0) | 35 (17.9) | 0.77 (0.37–1.58) |
| Met212/Val212 + Ile95/Ile95 | 2 (1.2) | 3 (1.5) | — |
| Val212/Val212 + Val95/Val95 | 22 (13.1) | 35 (17.9) | 0.45 (0.21–0.99)a |
| Val212/Val212 + Val95/Ile95 | 6 (3.6) | 3 (1.5) | — |
| Val212/Val212 + Ile/95/Ile95 | 0 | 0 | — |
a
Confidence interval of OR does not contain 1.0.