TABLE IV.
PEMT Met212Val and Val95Ile Compound Genotype, Maternal Choline Intake, and Risk of Spina Bifida
| Combined genotype | Cases (%) | Control (%) | OR (95% CI) |
|---|---|---|---|
| Overall | |||
| Met212/Met212 + Val95/Val95 | 10 (10.3) | 30 (9.1) | Referent |
| Met212/Met212 + Val95/Ile95 | 18 (18.6) | 73 (22.2) | 0.74 (0.31–1.79) |
| Met212/Met212 + Ile95/Ile95 | 10 (10.3) | 37 (11.3) | 0.81 (0.30–2.20) |
| Met212/Val212 + Val95/Val95 | 18 (18.6) | 64 (19.5) | 0.84 (0.35–2.05) |
| Met212/Val212 + Val95/Ile95 | 25 (25.8) | 71 (21.6) | 1.06 (0.45–2.47) |
| Met212/Val212 + Ile95/Ile95 | 6 (6.2) | 5 (1.5) | 3.60 (0.90–14.39) |
| Val212/Val212 + Val95/Val95 | 9 (9.3) | 40 (12.2) | 0.68 (0.24–1.87) |
| Val212/Val212 + Val95/Ile95 | 1 (1.0) | 9 (2.7) | 0.33 (0.04–2.97) |
| Val212/Val212 + Ile/95/Ile95 | 0 | 0 | — |
| Lower 25% percentile | |||
| Met212/Met212 + Val95/Val95 | 4 (12.9) | 9 (11.0) | Referent |
| Met212/Met212 + Val95/Ile95 | 6 (19.4) | 18 (22.0) | 0.75 (0.17–3.35) |
| Met212/Met212 + Ile95/Ile95 | 2 (6.5) | 9 (11.0) | 0.50 (0.07–3.45) |
| Met212/Val212 + Val95/Val95 | 6 (19.4) | 17 (20.7) | 0.79 (0.18–3.56) |
| Met212/Val212 + Val95/Ile95 | 6 (19.4) | 17 (20.7) | 0.79 (0.18–3.56) |
| Met212/Val212 + Ile95/Ile95 | 3 (9.7) | 1 (1.2) | 6.75 (0.53–86.56) |
| Val212/Val212 + Val95/Val95 | 4 (12.9) | 9 (11.0) | 1.00 (0.19–5.29) |
| Val212/Val212 + Val95/Ile95 | 0 | 2 (2.4) | — |
| Val212/Val212 + Ile/95/Ile95 | 0 | 0 | — |
| Higher 25% percentile | |||
| Met212/Met212 + Val95/Val95 | 6 (9.1) | 21 (8.5) | Referent |
| Met212/Met212 + Val95/Ile95 | 12 (18.2) | 55 (22.3) | 0.76 (0.25–2.30) |
| Met212/Met212 + Ile95/Ile95 | 8 (12.1) | 28 (11.3) | 1.00 (0.30–3.32) |
| Met212/Val212 + Val95/Val95 | 12 (18.2) | 47 (19.0) | 0.89 (0.30–2.70) |
| Met212/Val212 + Val95/Ile95 | 19 (28.8) | 54 (21.9) | 1.23 (0.43–3.51) |
| Met212/Val212 + Ile95/Ile95 | 3 (4.6) | 4 (1.6) | 2.63 (0.46–15.11) |
| Val212/Val212 + Val95/Val95 | 5 (7.6) | 31 (12.6) | 0.57 (0.15–2.09) |
| Val212/Val212 + Val95/Ile95 | 1 (1.5) | 7 (2.8) | 0.50 (0.05–4.90) |
| Val212/Val212 + Ile/95/Ile95 | 0 | 0 | — |
| Val212/Val212 + Ile/95/Ile95 | 0 | 0 | — |