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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Nat Neurosci. 2010 Jul 25;13(8):951–957. doi: 10.1038/nn.2601

Figure 6.

Figure 6

Effect of WWL70 and JZL184 on CB1-dependent LTD in mouse prefrontal cortex. Field potentials measured in layer 5 after stimulation in layer 2 (arrow, 5 min at 10 Hz). Both the area and amplitude of the field excitatory postsynaptic potential (fEPSP) were measured (graphs depict area). Slices were preincubated for 10 min with WWL70 (10 μM), JZL184 (1 μM) or vehicle (0.01% DMSO, control), and the inhibitors remained present in the superfusion medium throughout the experiment. (a) Time course and (b) summary of the 40-min time point. Data are mean ± s.e.m. of at least ten different brain slices. Statistical significance (above bars) was calculated relative to control (Mann Whitney).