Table 1. Factors associated with death from visceral leishmaniasis in children (univariate and multivariate analysis).
Variable | Dead(57)n(%) | Alive(489)n(%) | OR(95% CI) | Adjusted OR (95% CI) |
Clinical/demographic | ||||
Male sex | 20(35) | 255(52) | 0.53 (0.3–1.0) | |
Age <5 years old | 47(82) | 323(66) | 3.19 (1.4–7.5) | |
Severely malnourished* | 8(14) | 41(8) | 1.78 (0.7–4.2) | |
Diarrhea | 11(19) | 62(13) | 1.73 (0.8–3.7) | |
Edema | 27(47) | 69(14) | 5.87 (3.1–11.1) | |
Jaundice | 16(28) | 22(5) | 8.71 (3.9–19.1) | 4.4 (1.7–11.2) |
Dyspnea | 24(42) | 61(13) | 5.43 (2.8–10.3) | 2.8 (1.2–6.1) |
Mucosal bleeding | 10(17) | 10(2) | 10.69 (3.7–28.2) | 4.1 (1.3–13.4) |
Cutaneous bleeding | 18(32) | 31(6) | 6.82 (3.3–14.0) | |
Upper gastrointestinal bleeding | 4(7) | 1(0.2) | 38.27 (-) | |
Associated infections | 23(40) | 56(11) | 5.56 (2.9–10.7) | 2.7 (1.2–6.1) |
Laboratory † | ||||
Total leukocyte count<2,500/mm3 | 21(37) | 142(29) | 1.41 (0.8–2.6) | |
Total platelet count<50,000/mm3 | 43(75) | 90(18) | 15.01 (7.3–31.4) | 11.7 (5.4–25.1) |
Neutrophil count<500/mm3 | 17(30) | 66(14) | 2.68 (1.4–5.2) | 3.1 (1.4–6.9) |
Hemoglobin <5 g/dL | 31(54) | 103(21) | 4.43 (2.4–8.1) |
*Weight not available for 2 children.
†: Full blood count missing for 3children.