Table 2. Summary table of all septin interacting proteins identified and their functional assignments.
| Septin bait | Group | Septin preys (In order of frequency) | Predominant septin prey group | Non-septin preys in order of frequency (shared preys) | Functions of non-septins | Overlapping functions | |||||
| 1 | 2 | Septin 9,6,11,1,2,4,5 | Group 6 | UBE2I, CEP110, SKA1 | Protein degradation, cell division | C | U | ||||
| 2 | 2 | Septin 6, 4 | Group 6 | ANKZF1, DCTN2, CCDC45, PC-S/K-I, MAP3K12, ribosomal S6 Kinase like, UBE2I | Transport, Motor activity, microtubule-based process, kinase | T | M | P | C | U | |
| 4 | 2 | Septin 11, 10, 6, 8 | Group6 | UBE2I, VEGFR-1, CASC3 | Phosphorylation/Tyrosine kinase receptor, Protein degradation | P | C | U | |||
| 5 | 2 | Septin 6, 8, 11, 5, 2 | Group6 | UBE2I, SNX6 | Protein degradation, Intracellular Trafficking | T | C | U | |||
| 9 (9N) | 3 (3/9) | Septin 6, 7 | Group 6 | FLNA, SH3KBP1 | Cytoskeletal organization, apoptosis | T | C | ||||
| 3 | 3 (3/9) | Septin 6, 11 | Group 6 | UBE2I, CASP8AP2, PIAS3, TDG, ABCB10, ACTB, EIF 4A, EXOSC9, GABA-RAPL2, HNRNPH3, MYO1B, PLK2, PRDX2, RPL14, RPS24, STMN2, SUMO1, TMEM93, IFT27, TDG | Protein degradation, Cell motility, Apoptosis, DNA repair, SUMO ligase, Neuron differentiation, Splicing process, Phosphorylation, Translation, Signal transduction, kinase, Endocytosis | T | M | P | G | C | U |
| 6 | 6 | Septin 9, 5, 7, 1, 2, 4, 3 | Group 3 | UBE2I, SUMO1, CASP8AP2, PIAS3, TOPORS, ACTR2, HIPK3, MDH1 | Apoptosis, Cell cycle, SUMO cycle activity, Protein modification process, Ubiquitin cycle, Cell motility, Cell division, Protein degradation, kinase | P | C | U | |||
| 8 | 6 | Septin 9, 7, 4, 2, 5, 1 | Group 3 | C1QBP, CERCAM, CENP-F, SH2B3, UFD1L, CAPRIN1, ERP29, FAM89B, HDAC11, KIF14, LCP1, LMNB1, PBXIP1, PIAS3, SMARCC2, ZNF451 | Immune response, Cell division, Cell adhesion, cell motility, SUMO ligase activity, Cell cycle, intracellular protein transport, Transcription, microtubule motor activity, Cell differenciation, ubiquitin cycle | T | M | C | U | ||
| 10 | 6 | – | PLZF-ZBTB16 | cell cycle, transcription | C | ||||||
| 7 | 7 | Septin 9, 6, 4, 1, 10, 11 | Group 3 | RALBP1, ANKRD12, ZNF451 | Endocytosis, Transcriptional | G | C | ||||
Overlapping functions: T = Transport, endocytosis and cytoskeleton, M = Motoractivity, P = Phosphorylation, G = GAP Ras, C = Cell division, Cell cycle, U = Ubiquitin / Sumo cycles (Pias, Ube2I).