Table 3.
Deletion mutations found in canine GISTs in this study
| Case | Codon | DNA Mutation | Amino Acid |
|---|---|---|---|
| 2 | 556-557 | GTA CAG TGG AAG GTT GTT → GTA C_AG GTT GTT | VQWKVV → VQVV |
| 16 | 556-557 | GTA CAG TGG AAG GTT GTT → GTA C_AG GTT GTT | VQWKVV → VQVV |
| 1 | 556-558 | GTA CAG TGG AAG GTT GTT → GTA CAG T TT GTT | VQWKVV → VQFV |
| 5 | 556-558 | GTA CAG TGG AAG GTT GTT → GTA CAG T TT GTT | VQWKVV → VQFV |
| 12 | 556-558 | GTA CAG TGG AAG GTT GTT → GTA CAG T TT GTT | VQWKVV → VQFV |
| 15 | 556-558 | GTA CAG TGG AAG GTT GTT → GTA CAG T TT GTT | VQWKVV → VQFV |
The codon numbering is based upon the canine KIT amino acid sequence. The genomic DNA mutations were experimentally determined by direct sequencing and the altered sequence is underlined in column three. The expected amino acid changes in the protein are provided in column four. [GenBank: NC_006595.2, GenBank: NP_001003181].