Table 1.
General study characteristics of the two experimental groups (n = 5 in control and in in utero anaemia group)
| Control | In utero anaemia | |
|---|---|---|
| Prenatal | ||
| Surgery gestation age (days) | 113 ± 1 | 115 ± 1 |
| Start haemorrhage gestational age (days) | 117 ± 1 | 117 ± 1 |
| Initial carotid arterial pH | 7.398 ± 0.005 | 7.378 ± 0.017 |
| Initial pO2 (Torr) | 21.4 ± 0.5 | 21.0 ± 1.3 |
| Initial pCO2 (Torr) | 49.3 ± 1.2 | 48.9 ± 1.1 |
| Initial haematocrit (%) | 30 ± 2 | 32 ± 2 |
| Initial haemoglobin (g dL−1) | 9.84 ± 0.34 | 10.44 ± 0.64 |
| Initial oxygen content (mL dL−1) | 8.32 ± 0.40 | 7.98 ± 0.69 |
| Days anaemic (<50% initial haematocrit) | 0 | 14 ± 1* |
| Lowest haematocrit (%) | 29 ± 2 | 14 ± 1* |
| Lowest haemoglobin (g dL−1) | 9.58 ± 0.47 | 3.96 ± 0.17* |
| Lowest oxygen content (mL dL−1) | 8.06 ± 0.53 | 2.24 ± 0.10* |
| Volume blood transfused (mL) | 0 | 137.0 ± 5.4* |
| Birth | ||
| Gestation delivered (days) | 141 ± 1 | 142 ± 1 |
| Birth weight (kg) | 3.93 ± 0.41 | 3.17 ± 0.52 |
| Birth haematocrit (%) | 38 ± 7 | 29 ± 2 |
| Gender (f/m) | 3/2 | 3/2 |
| Adult | ||
| Age at final study (days) | 227 ± 3 | 228 ± 6 |
| Weight at study (kg) | 39.31 ± 2.07 | 41.86 ± 3.19 |
| Haematocrit at study (%) | 23 ± 1 | 27 ± 2 |
| Ventricle (LV + RV) weight (g) | 195.7 ± 8.7 | 229.4 ± 18.6 |
| LV weight (g) | 149.9 ± 8.5 | 176.1 ± 13.2 |
| RV weight (g) | 38.2 ± 4.6 | 53.3 ± 5.8 |
| Ventricle to body weight ratio (g kg−1) | 5.07 ± 0.32 | 5.54 ± 0.40 |
Values are mean ± SEM. pO2, arterial pO2; pCO2, arterial pCO2; f, female; m, male.
*
P < 0.001 compared with control.