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. Author manuscript; available in PMC: 2011 Oct 15.
Published in final edited form as: Mov Disord. 2010 Oct 15;25(13):2156–2163. doi: 10.1002/mds.23265

Figure 2. LRRK2 idiogram of domains, chromatogram of LRRK2 c.4309 C>A, Roc domain protein structure and conservation across species.

Figure 2

Molecular model of the Lrrk2 Roc domain highlighting in yellow the p.Asn1437His and p.Arg1441Cys/Gly/His variants was obtained from the NCBI MMDB database [MMDB ID# 64897 (PDB# 3D6T)] 22. Species conservation for the p.Asn1437His and adjacent amino acids was obtained from the UCSC Genome browser and the pathogenic p.Arg.1441 and putative pathogenic p.Ala1442 mutated residues are indicated with asterisks.