Table 2.
Estimated Probability of the Development of Vessel Pathology in 5- to 21-Month-Old Mice
| Age Group, Months |
||||
|---|---|---|---|---|
| 5 | 9 | 14 | 21 | |
| Female WT | 0.0000 | 0.0147 | 0.0909 | 0.1185 |
| Female HT | 0.0151 | 0.5799 | 0.8617 | 0.2653 |
| Male WT | 0.0000 | 0.1103 | 0.4546 | 0.5284 |
| Male HT | 0.1136 | 0.9201 | 0.9811 | 0.7506 |
HT, heterozygous; WT, wild-type.
The probability (P) of developing vessel pathology was estimated by a logistic regression model using combinations of the 3 variables age, genotype, and sex. Sex was highly significant—P(pathology | female) < P(pathology | male)—and the genotype–age group interaction was significant. The estimates probabilities show that P(pathology | HT) > P(pathology | WT) within each sex by age group.