Skip to main content
. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Heart Rhythm. 2010 Jul 3;7(11):1686–1694. doi: 10.1016/j.hrthm.2010.06.032

Figure 4.

Figure 4

Spatial and temporal heterogeneity of CaT and APs during LQT2

A: Isochronal Map of APD90 (A (a), top left) from the anterior surface in LQT2; the field-of-view of the array is shown (see inset d) and isochronal lines are 50 ms apart (see color scale). Cai signals recorded at each site are depicted in the symbolic map of the photodiode array (b). Simultaneous Vm and Cai from a single-beat are superimposed for pixels labeled 1, 2 and 3 on the maps and are shown at fast sweep speed (c). Marked spatial heterogeneities of CaiO appear; with the highest number of CaiO found at sites with the longest APDs and decrease in going to sites with shorter APDs.

B: EKG, Vm and Cai recordings from pixel (1) for 30 s show a gradual APD prolongation associated with an increasing number of CaiO and a rise of diastolic Cai. The right panel shows a shorter segment of the signals (in green box on left) with better time resolution.