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Effect of Reduced SR Ca2+ load on CaiO and TdP
TdP was induced with LQT2 solution then nifedipine (5 μM) was added (A) or external Ca2+ was lowered (100 μM) (B) in the perfusate. Both interventions attenuated CaiO and terminated TdP despite continuous dofetilide perfusion and marked APD prolongation.
