Figure 5. Glutathione peroxidase (GPx) activity is decreased with M. abscessus infection.
Differentiated THP-1 cells were uninfected, infected with M. abscessus or infected in the presence of MnTE-2-PyP for 0, 24, 48 or 72 hours. GPx activity was significantly decreased in cells infected with M. abscessus alone when compared to uninfected cells or cells infected in the presence of MnTE-2-PyP at 48 and 72 hours post-infection. Each experiment was normalized to the control 0 time point. All data represent the mean ± SEM, n=5. The asterisk (*) denotes significant change from the respective control (p< 0.05).