Skip to main content
. Author manuscript; available in PMC: 2011 Nov 15.
Published in final edited form as: Bioorg Med Chem. 2010 Sep 22;18(22):7957–7965. doi: 10.1016/j.bmc.2010.09.029

Table 1.

Anticonvulsant Activity and Toxicity of Compounds 3–29 Administered Intraperitoneally to Mice

Comp. Structure Dose MES(ip)a ScMetb Toxc
mg/kg 0.5hd 4hd 0.5hd 4hd 0.5hd 4hd
3 graphic file with name nihms241957t1.jpg mg/kg 100–300 >300 >300 >300 100–300 >300
4 graphic file with name nihms241957t2.jpg mg/kg 100–300 >300 >300 >300 100–300 >100
5 graphic file with name nihms241957t3.jpg mg/kg 100–300 100–300 >300 >300 100–300 100–300
6 graphic file with name nihms241957t4.jpg mg/kg >300 >300 >300 >300 >300 >300
7 graphic file with name nihms241957t5.jpg mg/kg 100–300 100–300 >300 >300 100–300 100–300
8 graphic file with name nihms241957t6.jpg mg/kg 100–300 100–300 100–300 >300 100–300 100–300
9 graphic file with name nihms241957t7.jpg mg/kg >300 >300 >300 >300 100–300 >300
10 graphic file with name nihms241957t8.jpg mg/kg >30e 100–300 >300 >300 100–300 100–300
11 graphic file with name nihms241957t9.jpg mg/kg >300 >300 >300 >300 >300 >300
12 graphic file with name nihms241957t10.jpg mg/kg 100–300 100–300 100–300 >300 100–300 >300
13 graphic file with name nihms241957t11.jpg mg/kg >30e 100–300 100–300 >300 100–300 100–300
14 graphic file with name nihms241957t12.jpg mg/kg >30e 100–300 >300 >300 >30e >300
15 graphic file with name nihms241957t13.jpg mg/kg 100–300 100–300 >300 100–300 >300 >300
16 graphic file with name nihms241957t14.jpg mg/kg 100–300 100–300 >300 >300 >300 >300
17 graphic file with name nihms241957t15.jpg mg/kg 100–300 100–300 >300 >300 >300 >300
18 graphic file with name nihms241957t16.jpg mg/kg >300 100–300 >300 >300 100–300 >300
19 graphic file with name nihms241957t17.jpg mg/kg >30e 100–300 >300 >300 100–300 >300
20 graphic file with name nihms241957t18.jpg mg/kg >30e 100–300 >300 >300 100–300 >300
21 graphic file with name nihms241957t19.jpg mg/kg >30e 100–300 100–300 >300 100–300 100–300
22 graphic file with name nihms241957t20.jpg mg/kg >30e >300 >300 >300 100–300 >300
23 graphic file with name nihms241957t21.jpg mg/kg 100–300 100–300 >300 >300 >300 >300
24 graphic file with name nihms241957t22.jpg mg/kg 100–300 100–300 >300 >300 >300 >300
25 graphic file with name nihms241957t23.jpg mg/kg 100–300 >300 >300 100–300 100–300 100–300
26 graphic file with name nihms241957t24.jpg mg/kg >30e 100–300 >300 >300 100–300 100–300
27 graphic file with name nihms241957t25.jpg mg/kg >300 >300 >300 >300 >300 >300
28 graphic file with name nihms241957t26.jpg mg/kg >300 100–300 >300 >300 >300 >300
29 graphic file with name nihms241957t27.jpg mg/kg >300 100–300 >300 >300 >300 >300
a

Maximal electroshock test (administered intraperitoneally to mice at doses ranging from 30 to 300 mg/Kg).

b

Subcutaneous metrazol test (administered intraperitoneally to mice at doses ranging from 30 to 300 mg/Kg).

c

Neurotoxicity (administered intraperitoneally to mice at doses ranging from 30 to 300 mg/Kg; no neurotoxicity detected for oral administration to rats).

d

Time of test after drug administration. Nd: Not determined.

e

MES activities > 30 means that these compounds show activities between 30–100 mg/kg.