Skip to main content
. Author manuscript; available in PMC: 2011 Nov 15.
Published in final edited form as: Bioorg Med Chem. 2010 Sep 22;18(22):7957–7965. doi: 10.1016/j.bmc.2010.09.029

Table 2.

Anticonvulsant Activity and Toxicity of Compounds 8, 10, 13, 16, 17, 19–22, 24 Administered Orally (30 mg/kg) to Rats

Compd Structure MESa TOXb
0.25hc 0.5hc 1hc 2hc 4hc
8 graphic file with name nihms241957t28.jpg 1/4 0/4 1/4 0/4 0/4 0/4 (−)d
10 graphic file with name nihms241957t29.jpg 2/4 2/4 1/4 0/4 0/4 0/4 (−)d
13 graphic file with name nihms241957t30.jpg 2/4 0/4 3/4 2/4 0/4 0/4 (−)d
16 graphic file with name nihms241957t31.jpg 0/4 0/4 1/4 0/4 1/4 0/4(−)d
17 graphic file with name nihms241957t32.jpg 0/4 1/4 2/4 1/4 2/4 0/4(−)d
19 graphic file with name nihms241957t33.jpg 0/4 0/4 0/4 0/4 0/4 0/4 (−)d
20 graphic file with name nihms241957t34.jpg 0/4 0/4 2/4 0/4 0/4 0/4 (−)d
21 graphic file with name nihms241957t35.jpg 0/4 0/4 0/4 0/4 1/4 0/4 (−)d
22 graphic file with name nihms241957t36.jpg 1/4 0/4 0/4 0/4 0/4 0/4 (−)d
24 graphic file with name nihms241957t37.jpg 0/4 0/4 0/4 0/4 0/4 0/4 (−)d
a

Maximal electroshock test (number of animals protected/number of animals tested).

b

Neurotoxicity (number of animals protected/number of animals tested).

c

Time after drug administration.

d

(−) No neurotoxicity at doses tested.