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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Cancer Res. 2010 Oct 14;70(21):8517–8525. doi: 10.1158/0008-5472.CAN-10-1242

Figure 1.

Figure 1

Drosophila Yki-S168A or human Yap-S127A overexpression induces tumorigenesis in the Drosophila ovary. A. Confocal section through wildtype Drosophila egg chamber (upper) stained with propidium iodide to reveal nuclei and with phalloidin to reveal cell cortices. Follicle cells (small nuclei, arrow heads) form a monolayer epithelium around the germ cells (large nuclei, arrows). In egg chambers in which all follicle cells overexpress fly Yki-S168A (middle) or human Yap-S127A (lower) the follicular epithelium becomes multilayered and has supernumerary follicle cells.