Skip to main content
. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: J Neurochem. 2010 Sep 28;115(3):635–642. doi: 10.1111/j.1471-4159.2010.06973.x

Figure 1. Effect of NK-3 receptor blockade on development of behavioral sensitization to cocaine.

Figure 1

Adult male CD-1 mice were injected with either vehicle or the NK-3 receptor antagonist SB 222200 (2.5, 5 mg/kg s.c.) 30 mins prior to a cocaine (20 mg/kg, i.p.) injection for 5 days. After a seven day drug-free period, all mice were challenged with cocaine (20 mg/kg, i.p.) and behavioral responses were measured. Within vehicle treatment groups, mice injected repeatedly with cocaine had significantly increased ambulatory activity to a subsequent cocaine challenge compared to saline animals indicating a sensitized behavioral response. Administration of SB 222200 blocked this sensitized behavioral response in mice injected with repeated cocaine. Data are presented as mean ± SEM; N=7–12 mice/group (* p<0.05, **p< 0.01).