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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: J Neurochem. 2010 Sep 28;115(3):635–642. doi: 10.1111/j.1471-4159.2010.06973.x

Figure 2. Effect of NK-3 receptor blockade on expression of behavioral sensitization to cocaine.

Figure 2

Adult male CD-1 mice were injected once daily with either saline or cocaine (20 mg/kg, i.p) for five days. After a seven day drug-free period, they were administered either vehicle or the NK-3 receptor antagonist SB 222200 (5 mg/kg, s.c.) 30 mins prior to a cocaine challenge (20 mg/kg, i.p.). SB 222200 administration 30 mins prior to a cocaine challenge did not significantly alter ambulatory activity in saline treated mice, but blocked the enhanced behavioral response to cocaine in mice given repeated cocaine. Data are presented as mean ± SEM; N=7–14 mice/group (* p<0.05).