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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Cancer Res. 2010 Oct 26;70(21):8329–8338. doi: 10.1158/0008-5472.CAN-10-2179

Figure 6. Medium conditioned by CAG HPSE-high cells induces osteoclastogenesis via increased RANKL.

Figure 6

Human PBMCs were cultured in conditioned medium from CAG cells expressing either low or high levels of heparanase (HPSE-low or HPSE-high) in the presence or absence of OPG. Addition of recombinant human (rh) RANKL was used as a positive control. The negative control was cells cultivated only with DMEM and mCSF. *** p< 0.001 compared to “no OPG” group.