Figure 2. Normal corticothalamic and thalamocortical trajectories in E16.5 GPR55 KO mice.
(A,B) The DiI-labeled corticothalamic tracts reach the thalamus and the morphology of the axonal tracts appears normal in GPR55 KO mice (B) and no different from their wild type littermates (A). (C,D) DiI-labeled thalamocortical axons target the cortical plate and the axonal fascicles appear normal in the GPR55 KO (D), and their littermate control (C) mice. (Panels 1–6) Projected images of 3-D confocal image stacks for the areas indicated in A–D. Abbreviations: cp, cortical plate; ge, ganglionic eminence; ic, internal capsule; lv, lateral ventricle; RT, reticular nucleus; st, striatum.