Figure 5.
Incidence of wound- and DMBA/TPA-induced papillomas in wild-type and Sp2-C hemizygotes. A, percentage of surgical wounds that produced papillomas in wild-type and Sp2-C hemizygous littermates in animals between 1 and 20 months of age. Columns, mean (wild-type, n = 11 mice/group; Sp2-C, n = 48 mice/group); bars, SE. B, percentage of Sp2-C hemizygotes that developed wound-induced papillomas as a function of age at time of surgery. Columns, mean (1 to 4 months, n = 9 mice/group; 6 to 10 months, n = 17 mice/group; 12 to 20 months, n = 22 mice/group); bars, SE. C, mean number of DMBA/TPA-induced papillomas per animal (wild-type, n = 8 mice/group; Sp2-C, n = 14 mice/group) are plotted as a function of age at time of DMBA treatment. Bars, SE.