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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: J Neurochem. 2010 Sep 28;115(3):551–562. doi: 10.1111/j.1471-4159.2010.06978.x

Fig 1.

Fig 1

A model for dietary link to dementia via metabolic disorders. It is argued that the two key pathogenic processes associated with metabolic disorders i.e., inflammation and insulin resistance may re-emerge within the brain due to cerebrovascular dysfunction with increased BBB permeability allowing macrophage/cytokine entry and reduced transport of trophic factors. Potential signaling pathways that further lead to AD-like molecular and cognitive changes via increased Aβ and tau phosphorylation are illustrated in Fig 2.