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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Cancer Res. 2010 Sep 17;70(21):8282–8287. doi: 10.1158/0008-5472.CAN-10-2205

Figure 1. Induction of alkaline phosphatase.

Figure 1

A. E1A 12S wild type (12S.WT) targets the p300 and pRB families. Mutant variants 12S.YH47/928 and 12S.RG2 carry missense mutations respectively inactivating binding of the pRB or p300 families.

B. Northern Blot showing the time course of alkaline phosphatase induction in normally differentiating osteoblasts.

C. In situ staining for alkaline phosphatase activity at day-7 post-induction.

D. In situ staining for alkaline phosphatase activity in lines where BRM or BRG1 are targeted by shRNA-mediated knockdown (K/D).