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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Cancer Res. 2010 Sep 17;70(21):8282–8287. doi: 10.1158/0008-5472.CAN-10-2205

Figure 3. Recruitment of RNA polymerase-II and dissociation of KDM5A.

Figure 3

A. ChIP analysis shows the timing of Alpl occupation by basal transcription factors in normal parental cells, compared with lines in which BRG1 is depleted or the E1A targets are sequestered. Primers corresponding to the 3’UTR of Alpl were included as a negative control in parental cells where promoter occupation was positive throughout the time course.

B. ChIP analysis shows the methylation status of H3K4 and the promoter occupation dynamics of KDM5A/RBP2 on Alpl during differentiation in normal parental cells, compared with lines in which the E1A targets are sequestered. A 3’UTR control was included as described in panel A.