Table 2.
The Association Between p53 Pathways Genotypes and Age at Diagnosis
| SNP | All patients | > 60 (yrs) |
≤ 60 (yrs) |
|||
|---|---|---|---|---|---|---|
| N (%) | N (%) | N (%) | OR* (95% CI) | P value** | ||
| p53 Arg72Pro (rs1042522) | ||||||
| CC | 274 (6.9) | 161 (7.9) | 113 (6.0) | Ref | 0.021 | |
| CG | 1593 (40.4) | 797 (38.9) | 796 (42.0) | 1.42 | (1.10–1.85) | |
| GG | 2080 (52.7) | 1092 (53.2) | 988 (52.0) | 1.29 | (1.00–1.66) | |
| total | 3947 (100.0) | 2050 (100.0) | 1897 (100) | |||
| Mdm2 SNP 309 (rs2279744) | ||||||
| GG | 557 (14.1) | 320 (15.6) | 237 (12.5) | Ref | 0.004 | |
| GT | 1842 (46.7) | 964 (47.1) | 878 (46.3) | 1.23 | (1.02–1.49) | |
| TT | 1546 (39.2) | 764 (37.3) | 782 (41.2) | 1.38 | (1.14–1.68) | |
| total | 3945 (100.0) | 2048 (100.0) | 1897 (100.0) | |||
| Mdm4 (rs1380576) | ||||||
| GG | 408 (10.3) | 214 (10.4) | 194 (10.1) | Ref | 0.945 | |
| CG | 1674 (42.1) | 871 (42.2) | 803 (42.0) | 1.02 | 0.82–1.26 | |
| CC | 1894 (47.6) | 978 (47.4) | 916 (47.9) | 1.03 | 0.83–1.28 | |
| total | 3976 (100.0) | 2063 (100.0) | 1913 (100.0) | |||
| Hausp (rs1529916) | ||||||
| GG | 1968 (49.4) | 1046 (50.7) | 922 (48.1) | Ref | 0.074 | |
| GA | 1652 (41.5) | 822 (39.8) | 830 (43.3) | 1.15 | (1.01–1.31) | |
| AA | 360 (9.1) | 196 (9.5) | 164 (8.6) | 0.95 | (0.76–1.19) | |
| total | 3980 (100.0) | 2064 (100.0) | 1916 (100.0) | |||
*
Odds Ratio of having early onset prostate cancer (≤ 60 yrs).
**
P values for Wald Chi-square tests.