Table 3.
Genotype frequencies, odds ratios and 95% CI comparing D’Amico Risk Classes
| SNP | N (%) |
OR (95% CI)* |
||||||
|---|---|---|---|---|---|---|---|---|
| Low | Intermediate | High | Intermediate vs. Low | High vs. Low | P value† | |||
| p53 Arg72Pro (rs1042522) | ||||||||
| CC | 70 (7.0) | 91 (6.8) | 79 (8.2) | Ref | Ref | 0.938 | ||
| CG | 407 (40.7) | 548 (40.7) | 395 (40.8) | 1.11 | (0.79–1.56) | 0.93 | (0.65–1.33) | |
| GG | 523 (52.3) | 709 (52.6) | 494 (51.0) | 1.09 | (0.78–1.53) | 0.88 | (0.62–1.25) | |
| total | 1000 (100.0) | 1348 (100.0) | 968 (100.0) | |||||
| Mdm2 SNP 309 (rs2279744) | ||||||||
| GG | 142 (14.2) | 194 (14.4) | 125 (12.8) | Ref | Ref | 0.810 | ||
| GT | 452 (45.4) | 626 (46.5) | 454 (46.7) | 1.03 | (0.80–1.32) | 1.19 | (0.90–1.58) | |
| TT | 402 (40.4) | 526 (39.1) | 394 (40.5) | 0.98 | (0.76–1.28) | 1.17 | (0.88–1.55) | |
| total | 996 (100.0) | 1346 (100.0) | 973 (100.0) | |||||
| Mdm4 (rs1380576) | ||||||||
| GG | 122 (12.1) | 126 (9.3) | 90 (9.1) | Ref | Ref | 0.023 | ||
| CG | 396 (39.5) | 597 (44.1) | 397 (40.4) | 1.47 | (1.11–1.95) | 1.38 | (1.01–1.89) | |
| CC | 485 (48.4) | 632 (46.6) | 496 (50.5) | 1.31 | (0.99–1.74) | 1.50 | (1.10–2.04) | |
| total | 1003 (100.0) | 1355 (100.0) | 983 (100.0) | |||||
| Hausp (rs1529916) | ||||||||
| GG | 517 (51.5) | 669 (49.4) | 472 (47.9) | Ref | Ref | 0.046 | ||
| GA | 413 (41.1) | 550 (40.6) | 420 (42.6) | 1.04 | (0.87–1.24) | 1.12 | (0.93–1.35) | |
| AA | 74 (7.4) | 136 (10.0) | 94 (9.5) | 1.44 | (1.06–1.97) | 1.39 | (0.99–1.94) | |
| total | 1004 (100.0) | 1355 (100.0) | 986 (100.0) | |||||
*
adjusted by the age at diagnosis.
†
P values for Wald Chi-square tests.