Table 4.
Genotype frequencies, odds ratios and 95% CI comparing RP Gleason <7 and ≥ 7
| SNP | Gleason < 7 |
Gleason ≥ 7 |
|||
|---|---|---|---|---|---|
| N (%) | N (%) | OR (95%CI) * | P value† | ||
| p53 Arg72Pro (rs1042522) | |||||
| CC | 43 (6.6) | 72 (7.0) | Ref | 0.923 | |
| CG | 266 (41.0) | 425 (41.4) | 1.05 | (0.69–1.61) | |
| GG | 340 (52.4) | 529 (51.6) | 0.98 | (0.64–1.48) | |
| total | 649 (100.0) | 1026 (100.0) | |||
| Mdm2 SNP 309 (rs2279744) | |||||
| GG | 107 (16.6) | 137 (13.3) | Ref | 0.004 | |
| GT | 312 (48.4) | 450 (43.8) | 1.12 | (0.83–1.51) | |
| TT | 226 (35.0) | 441 (42.9) | 1.51 | (1.11–2.05) | |
| total | 645 (100.0) | 1028 (100.0) | |||
| Mdm4 (rs1380576) | |||||
| CC | 89 (13.6) | 109 (10.5) | Ref | 0.047 | |
| CG | 281 (43.1) | 434 (41.7) | 1.31 | (0.94–1.84) | |
| GG | 282 (43.3) | 497 (47.8) | 1.50 | (1.07–2.09) | |
| total | 652 (100.0) | 1040 (100.0) | |||
| Hausp (rs1529916) | |||||
| GG | 332 (50.9) | 509 (48.9) | Ref | 0.628 | |
| GA | 264 (40.5) | 430 (41.4) | 1.04 | (0.84–1.29) | |
| AA | 56 (8.6) | 101 (9.7) | 1.24 | (0.86–1.80) | |
| total | 652 (100.0) | 1040 (100.0) | |||
*
adjusted by the age at diagnosis.
†
P values for Wald Chi-square tests.