Table 2. Clinical (A.) and laboratory (B.) toxicity in patients treated with Ad5-Δ24-RGD by category and grade.
| A. | |||||
|---|---|---|---|---|---|
| Body System | Toxicity Grades (NCI CTC V.3) | Total Occurrences | |||
| 1 | 2 | 3 | 4 | ||
| Gastrointestinal | 61 | 34 | 6 | 0 | 101 |
| Constitutional | 18 | 6 | 0 | 0 | 24 |
| Pain | 10 | 8 | 1 | 0 | 19 |
| Neurology | 4 | 4 | 0 | 0 | 8 |
| Infection | 1 | 6 | 0 | 0 | 7 |
| Dermatology/Skin | 0 | 4 | 1 | 0 | 5 |
| Cardiac General | 2 | 2 | 0 | 0 | 4 |
| Lymphatics | 3 | 1 | 0 | 0 | 4 |
| Musculoskeletal | 3 | 1 | 0 | 0 | 4 |
| Allergy/Immunology | 3 | 0 | 0 | 0 | 3 |
| Syndromes | 0 | 2 | 0 | 0 | 2 |
| Respiratory | 0 | 0 | 1 | 0 | 1 |
| Renal/Genitourinary | 0 | 1 | 0 | 0 | 1 |
| Blood/Bone Marrow | 1 | 0 | 0 | 0 | 1 |
| Cardiac Arrhythmia | 1 | 0 | 0 | 0 | 1 |
| B. | |||||
|---|---|---|---|---|---|
| Lab Tests | Toxicity Grades (NCI CTC V.3) | Total Occurrences | |||
| 1 | 2 | 3 | 4 | ||
| Hemoglobin | 42 | 7 | 0 | 0 | 49 |
| Hematocrit | 34 | 12 | 0 | 0 | 46 |
| Glucose | 24 | 5 | 0 | 0 | 29 |
| Potassium | 11 | 1 | 1 | 0 | 14 |
| LDH | 8 | 2 | 0 | 0 | 10 |
| Creatinine | 6 | 0 | 0 | 0 | 6 |
| GGT | 4 | 1 | 0 | 0 | 5 |
| WBC | 5 | 0 | 0 | 0 | 5 |
| Sodium | 2 | 3 | 0 | 0 | 5 |
| Alkaline Phosphatate | 5 | 0 | 0 | 0 | 5 |
| Calcium | 2 | 2 | 0 | 0 | 4 |
| Phosphorous | 2 | 2 | 0 | 0 | 4 |
| Bicarbonate | 4 | 0 | 0 | 0 | 4 |
| Chloride | 0 | 2 | 0 | 0 | 2 |
| BUN | 2 | 0 | 0 | 0 | 2 |
| Total Bilirubin | 1 | 0 | 0 | 0 | 1 |
| Uric Acid | 0 | 0 | 0 | 0 | 0 |
| Platelet | 0 | 0 | 0 | 0 | 0 |