Figure 2.

Effects of lentiviral-mediated overexpression of angiotensin-converting enzyme (ACE)2 and angiotensin (Ang)-(1–7) in bleomycin-induced pulmonary hypertension. Bleomycin administration caused a significant increase in the right ventricular systolic pressure (RVSP) after 2 weeks, which was completely attenuated by lenti-ACE2 and lenti–Ang-(1–7) treatment. Data are represented as mean ± SEM. *P < 0.05 versus control group, ^#P < 0.05 versus bleomycin, ^¶P < 0.05 versus bleomycin + empty virus (n = 5–6 per group).