Figure 1.

A: Domain architectures of selected proteins that contain FYRN and FYRC motifs. For convenience only the C-terminal regions of MLL and MLL2 are shown. The taspase1 cleavage sites in MLL are indicated with arrows. ATX1, JMJ16 and AtMBD9 are all proteins from Arabidopsis thaliana. ATX1 is a histone H3K4 methylase⁴ and JMJ16 is a Jumonji C (JmjC) domain containing histone H3K4 demethylase.⁵ AtMBD9 is a methyl-CpG binding domain (MBD) containing protein involved in plant development.⁶ Q01FM8 is a chromodomain helicase from the alga Ostreococcus tauri.⁷ The domains shown are those identified by the SMART database.⁸ B: Crystal structure of the FYR domain of TBRG1 shown as ribbon model in stereoview. Secondary structure elements are labeled. The FYRN and FYRC regions are colored in blue and red, respectively.