Fig 1.

Model Neocortical Neuron and Window of Synaptic Plasticity. (a) Response of the two-compartment model neuron to Poisson distributed excitatory and inhibitory synaptic inputs at random locations on the dendrite. (b) Example of a backpropagating action potential in the dendrite of the model neuron as compared to the corresponding action potential in the soma (enlarged from the initial portion of the trace in (a)). (c) Window for synaptic plasticity in the model neuron obtained by varying the delay between presynaptic stimulation and postsynaptic spiking (negative delays refer to cases where presynaptic stimulation occurred before the postsynaptic spike).