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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: Exp Neurol. 2010 Sep 15;226(2):259–264. doi: 10.1016/j.expneurol.2010.08.019

Figure 3.

Figure 3

LEFT: The effect of LCN stimulation on mean MEP amplitude across the 10-minute recording window is frequency dependent, with maximal increase observed at 30 Hz. RIGHT: The persistence of the LCN stimulation effect across the 10-minute recording window is frequency dependent. The mean response is shown as a function of time for each of the five frequency levels, with the initial 10 minutes of data representing the “off” condition, followed by the 10 minute “on” block. With the exception of 100 Hz, all frequency groups show an initial increase in response magnitude at the start of LCN stimulation. At 50 Hz however, the effect is transient, with the response approximating baseline levels by the end of the 10 minute block. A similar pattern is seen for stimulation at 40 Hz, though the decrement is less dramatic. The enhancement is sustained at both 20 and 30 Hz, while there appears to be a negative effect of 100 Hz stimulation on cortical excitability over time.