Figure 2.

Microhomogeneity of a glioblastoma. (a) H&E stained section demonstrating two distinct cell morphologies with a nodule of large cells in the lower center surrounded by small cells in the upper portions of the photograph. (b) MIB-1 immunohistochemistry demonstrates the nodule of large cells in the lower center to have a low proliferation index relative to the small cells. (c) Neurofilament protein immunohistochemistry shows axons coursing through the small cells in the upper left region of the tumor (asterisk) with loss of axons in the upper right (arrowhead) and in the nodule of large cells (arrow).